Before SNL, Meyers got his improv comedy start as a member of the Northwestern University improv sketch group Mee-Ow. He continued his career at ImprovOlympic with the group Preponderate as well as overseas as a cast member of Boom Chicago, an English language improv troupe based in Amsterdam. Meyers joined the SNL cast in 2001.In 2005, he was promoted to writing supervisor and in January 2006 he became co-head writer, sharing the role with Tina Fey and Andrew Steele

Outside of SNL Meyers has appeared with Brendan Fraser in the 2008 3D film Journey to the Center of the Earth. Meyers is currently writing and will star in a movie called Key Party. He also starred in the 2004 comedy See This Movie with John Cho. Meyers has hosted the Webby Awards twice, in 2008 and 2009. Meyers also hosted the 2010 and 2011 ESPY Awards on ESPN. In 2011, Seth Meyers was the keynote speaker at the White House Correspondents Association Dinner on April 30.